E's

Tom refused to visit his fiancée's parents.

This sentence employs two a's, two c's, two d's, twenty-eight e's, five f's, three g's, eight h's, eleven i's, three l's, two m's, thirteen n's, nine o's, two p's, five r's, twenty-five s's, twenty-three t's, six v's, ten w's, two x's, five y's, and one z.