noun ·Rare ·Advanced level

Definitions

Noun

1. 1
   The suppression of a response to a stimulus countable, uncountable
2. 2
   The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity countable, uncountable

Etymology

From down- + regulation.

Data sourced from Wiktionary, WordNet, CMU, and other open linguistic databases. Updated March 2026.