Methotrexate

//ˌmɛθ.əˈtɹɛk.seɪt// noun

noun ·Rare ·Advanced level

Definitions

Noun
  1. 1
    An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic pregnancies. countable, uncountable

    "One group would be treated with intensive methotrexate dosing, while the other group would be treated with milder and less intensive dosing."

  2. 2
    toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis wordnet

Synonyms

All synonyms
amethopterinamethopterinmethotrexate sodium

Example

More examples

"One group would be treated with intensive methotrexate dosing, while the other group would be treated with milder and less intensive dosing."

Etymology

Probably from metho- + tre- (“alteration of pteridine”) + (carbo)x(yl)ate.

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Data sourced from Wiktionary, WordNet, CMU, and other open linguistic databases. Updated March 2026.