Nociplastic
adj ·Rare ·Advanced level
Definitions
- 1 Of, pertaining to, or resulting from plasticity, of a kind analogous to neuroplasticity, in parts of the central nervous system concerned with nociception. not-comparable
"Patients with rheumatic conditions often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain."
Example
More examples"Patients with rheumatic conditions often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain."
Etymology
Blend of nociceptive + neuroplastic, or perhaps noci- + plastic.
Related phrases
More for "nociplastic"
Data sourced from Wiktionary, WordNet, CMU, and other open linguistic databases. Updated March 2026.