Nucleotide

/ˈn(j)u(ː)kliəˌtaɪd/ noun

noun ·Rare ·Advanced level

Meaning at a glance

  • Primary sense: The monomer constituting DNA or RNA biopolymer molecules. Each nucleotide consists of a nitrogenous heterocyclic base (or nucleobase), which can be either a double-ringed purine or a single-ringed pyrimidine; a five-carbon pentose sugar (deoxyribose in DNA or ribose in RNA); and a phosphate group.
  • Grammar: nucleotide is listed as noun.
  • Nearest alternatives: adenosine triphosphate, base, building block, dna.
  • Useful contrasts: non-nucleotide, nucleoside.
  • Usage evidence: With a genome of only 400 million or so nucleotide bases, the pufferfish, Fugu rubripes rubripes, has the smallest known genome of any vertebrate animal. […] But the region of DNA between the landmarks can be a million or more nucleotides long.

How to use "nucleotide"

  1. Start with the primary definition, then check the part of speech before placing the word in a sentence.
  2. Compare nearby synonyms to make sure "nucleotide" carries the exact meaning, tone, and strength you need.
  3. Use the example sentence as a context check. If your sentence uses the word differently, confirm that the grammar still fits.

Meaning check

  • Does the word fit the sentence's grammar?
  • Does it match the intended tone rather than only the dictionary definition?
  • Would a simpler synonym be clearer for the reader?
  • Is there enough surrounding context to prevent ambiguity?

Source and review context

This entry combines structured lexical data with WordToolSet review checks. Definitions, examples, synonyms, and usage notes may come from different source tables, so the page is designed to show evidence from more than one angle before you rely on "nucleotide" in a final draft.

If a word has several senses, prefer the sense that matches your sentence's grammar and surrounding context. A correct definition can still be the wrong choice when the sentence needs a different register, emphasis, or level of specificity.

Before you rely on this definition

Read the first definition as a starting point, then check the example, synonyms, and part of speech before treating "nucleotide" as the right word for your sentence.

If your draft is formal, technical, persuasive, or sensitive, compare "nucleotide" with a nearby alternative so the final choice matches both meaning and reader expectation.

Compare nearby meanings

  • Use synonyms when you need a softer, stronger, simpler, or more specific word.
  • Use antonyms to check the boundary of the meaning and avoid accidental contrast.
  • Use the example sentence to confirm the word behaves naturally in context.
  • Keep the original wording when a replacement adds complexity without improving precision.

Definition decision workflow

1. Identify the role

Check whether "nucleotide" is acting as noun in your sentence. A definition is only useful when the grammar matches the way the word is being used.

2. Test the nearest option

Compare it with "adenosine triphosphate" and other nearby choices to see whether the sentence needs a softer, stronger, or more familiar word.

3. Confirm with context

Use the example sentence below as an evidence check, then read your own sentence out loud to catch tone or rhythm problems.

Review note: Definition pages are checked for source coverage, sentence evidence, synonym support, and editorial insight before they are treated as approval-ready pages. If the evidence is too thin, the page remains available to users but is kept out of the approval-facing indexed inventory.

Final meaning check

Before publishing a sentence with "nucleotide", ask whether the word helps the reader understand the idea faster. A precise word should reduce confusion, not simply make the sentence look more polished.

When the definition, synonym evidence, and example context point in the same direction, the word is usually a safer choice. When they conflict, revise the sentence or choose a clearer alternative.

Definitions

Noun
  1. 1
    The monomer constituting DNA or RNA biopolymer molecules. Each nucleotide consists of a nitrogenous heterocyclic base (or nucleobase), which can be either a double-ringed purine or a single-ringed pyrimidine; a five-carbon pentose sugar (deoxyribose in DNA or ribose in RNA); and a phosphate group.

    "With a genome of only 400 million or so nucleotide bases, the pufferfish, Fugu rubripes rubripes, has the smallest known genome of any vertebrate animal. […] But the region of DNA between the landmarks can be a million or more nucleotides long."

  2. 2
    a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) wordnet

Synonyms

All synonyms
adenosine triphosphatebasebuilding blockdnaenergy carrierenergy currency

Example

"With a genome of only 400 million or so nucleotide bases, the pufferfish, Fugu rubripes rubripes, has the smallest known genome of any vertebrate animal. […] But the region of DNA between the landmarks can be a million or more nucleotides long."

Common questions

What does "nucleotide" mean?

The monomer constituting DNA or RNA biopolymer molecules. Each nucleotide consists of a nitrogenous heterocyclic base (or nucleobase), which can be either a double-ringed purine or a single-ringed pyrimidine; a five-carbon pentose sugar (deoxyribose in DNA or ribose in RNA); and a phosphate group.

What is a synonym for "nucleotide"?

Common synonyms include: adenosine triphosphate, base, building block, dna, energy carrier, energy currency.

How do you use "nucleotide" in a sentence?

With a genome of only 400 million or so nucleotide bases, the pufferfish, Fugu rubripes rubripes, has the smallest known genome of any vertebrate animal. […] But the region of DNA between the landmarks can be a million or more nucleotides long.

How do you pronounce "nucleotide"?

Pronounced /ˈn(j)u(ː)kliəˌtaɪd/.

Etymology

From nucleo- (“relating to the nucleus”) + -ide (“chemical suffix”).

More for "nucleotide"