Allotypy

Other allotypies have been found in 1961 by Benaceraff and Gell [32] in guinea-pigs, likewise in 1961 by Kelus and Moor-Jankowski in mice [219] and in baboons [220], in 1963 by Greuter and Butler [159] in Rhesus monkeys, ...

Since the differences in amino acid sequence associated with allotypy are small, rabbit IgG molecules of different allotype share most of their antigenic specificities.

Oudin named these reactive serum components allotypes and further concluded that it is reasonable to suppose that allotypy is not an unusual phenomenon, particularly with regard to certain rabbit serum proteins, that it might also be expected to occur in other species, and that the phenomenon may have a genetic basis, a proposition arising from the individual rabbit diversity of allotypic reactivity.