Dysmegakaryocytopoiesis

1985, Grover C. Bagby, The Preleukemic Syndrome (Hemopoietic Dysplasia), CRC PressI Llc The marrow also showed megakaryocytosis and severe dysmegakaryocytopoiesis with numerous micromegakaryocytes and micromegakaryoblasts.

In addition, dysmegakaryocytopoiesis, iron-laden macrophages, plasma cells and lymphoid infiltrates might be better identified in histologic sections.

Dysmegakaryocytopoiesis may include hypolobulated, hyperlobulated, or multinucleated megakaryocytes, or a reduction in their number or size.

Dysmegakaryocytopoiesis includes large megakaryocytes with unsegmented nuclei, micromegakaryocytes, and megakaryocytes with two or more small, unconnected nuclei. Megakaryocytes may be decreased in number.

Moderate thrombocytopenia due to dysmegakaryocytopoiesis, platelet dysfunction, reticulocytosis, and globin synthesis imbalance resembling beta-thalassemia have been described among patients with X-linked thrombocytopenia with beta-thalassemia.