Hematin

When the stain is of recent date, or supposed to be so, the red corpuscles should be particularly examined, and every care should be taken to preserve them without change. The stains must not be washed with water, so that the hæmatin may not be altered.

A urinary pH of 5.6 or less causes myoglobin to dissociate into globin and hematin (Reilly & Salluzzo, 1990).

This study was a multi-center, randomized, double-blind, placebo-controlled clinical trial in premenopausal women between 18 and 50 years old with cyclic (22 to 35 days) abnormal uterine bleeding in ≥4 of the last 6 menstrual cycles, menstrual blood loss ≥80 mL as measured by the alkaline hematin method over the first 8 days of menses, ≥1 discrete uterine fibroid of any size and location observable by transvaginal ultrasound, follicle-stimulating hormone ≤20 mIU/mL, and uterine volume ≤20 weeks by exam.