Hypoactivate

Among the various effects, they hyperactivate, hypoactivate, or inhibite limbic and other circuits, disorganize circuit activity, and interfere with effective functioning of the organism.

If the DLPFC of schizophrenic patients operates less efficiently than that of controls, patients may be found to hyperactivate this region as they strain to keep up with low working memory loads that control subjects can easily handle, and hypoactivate this region at higher working memory loads that exceed patients’ working memory capacity, but not that of controls.

The mix-1 gene is known to hypoactivate the X chromosome and regulates the morphology of the male tail in C. elegans.