Impuissance

This fault, for a man not to be able to know himselfe betimes, and not to feele the impuissance and extreme alteration, that age doth naturally bring,[…]hath lost the reputation of the most part of the greatest men in the world.

[A]ll which things, bring perill to thoſe that know not how to uſe them well; and neither honour and credit, nor puiſſance, but rather argue their feebleneſse and impuiſſance.