Ipsc

The fact that only a small fraction of cells infected with the reprogramming factors form iPSC colonies indicates that direct reprogramming is a stochastic process.

One of the most promising routes in this regard is the generation of induced pluripotent stem cells (iPSC) by reprogramming cells.

ECs Derived from ESC and iPSC

[...] the propensity of stem cells to form teratoma following transplantation is still another major obstacle in using iPSC for disease therapy.

The preparation of somatic cells, their reprogramming and the subsequent verification of iPSC pluripotency are laborious, manual processes [....]