Keratorhexis

This area then was flattened out near the sclera. It was not cone-shaped as in keratoconus, but cylindrical. In differential diagnosis Jauernig considered keratoconus, keratectasia and keratorhexis.

One patient experienced conjunctivitis-induced keratorhexis after multiple administrations of EMD72000 at DL 3 (1,200 mg), which resolved within 1 week after symptomatic treatment.

Treatment-related grade 3-5 adverse events (AEs; cut-off date 11/23/10) included 1 sudden death, unknown etiology, at Day 7 in Arm A (36 mg/kg), neutropenia (n=4, all Arm B), proteinuria (n=3), thrombocytopenia (n=2), hypertension (n=2), and one each of fatigue, keratorhexis, and peripheral edema.