Lipointoxicate

Overall, these data suggest that bronchial epithelial cells are lipointoxicated by hypoxia-related Palmitate accumulation in CF patients.

A particularly preferred compound according to the invention is mannide monooleate, the inventors of which have shown, using mammalian pancreatic β-cells lipointoxicated by saturated fatty acids, that it is advantageously able to increase insulin secretion in subjects suffering from lipointoxication and/or type 2 diabetes mellitus by promoting in said subjects the maturation of proinsulin to insulin.

Lipointoxicated bronchial epithelial cells display aberrant, highly ordered, internal membranes.