Minicolumnopathy

Brain size is therefore not a confound to the reported minicolumnopathy of autistic patients.

The initial results suggesting a minicolumnopathy in autism have been reproduced in two independent samples.

The analysis of the current state of research in this area is guided by theoretical concepts developed in our laboratory, namely the neurodevelopmental “minicolumnopathy” hypothesis of autism that predicts an abnormal E/I ratio, GABA deficits, and gamma oscillation abnormality in autism (Casanova et al., 2002, 2003, 2015, 2015).