Monotrope

Since α-carbamazepine is a monotrope of γ-carbamazepine, and γ-carbamazepine is an enantiotrope of β-carbamazepine, the physical stability hierarchy depends on the transition temperature of β- and γ-carbamazepine.

Differential scanning calorimetry (DSC) or differential thermal analysis (DTA) scans (Section 5.5.3) can be employed to distinguish an enantiotrope from a monotrope.

These can be differentiated on a thermal scan where an endothermic transition indicates enantiotropes and an exothermic transition indicates monotropes.