Nonnitrogenic

In most instances sulfonium and phosphonium compounds yielded only weak ganglionic blocking agents. However, ten thiophanium and bisphosphonium compounds point to a possibility of developing highly active and valuable agents in the nonnitrogenic onium class.

One hundred grams of MF Feed (Oriental Yeast Co., Ltd., Tokyo) contained 24.6 g protein, 5.6 g lipids, 6.4 g minerals, 3.1 g fiber, 25.3 g soluble nonnitrogenic substances, and 8 g water.

The efficiency of bisphosphonates to reduce bone reabsorption appears to reside in their avidity to bind to bone mineral as well as their intracellular activity in osteoclasts. As a rule, nitrogenic bisphosphonates are more efficacious compared with nonnitrogenic bisphosphonates.