Odontomalacia

Professor J. Erdheim in 1906 showed that, from the time the parathyroids were removed from rats, the newly laid down dentinoid was no longer calcified. Odontomalacia (if there is any such word) developed.

Osteomalacia and odontomalacia in XLH have increased osteopontin in the matrix.

Skeletal complications in XLH patients include rickets and osteo/odontomalacia, with clinical manifestations including delayed walking, leg bowing (genu varum) or knock knees (genu valgum), growth failure and dental issues such as the occurrence of “spontaneous” tooth abscesses in the absence of caries or trauma.