Reaccommodates

The fact that a mutation of a mutation of residue 45 generates high mobility of a region of loop 3 located at ~ 20 Å of distance is explained because of a rearrangement of residue V77 that reaccommodates to allow the packing of Y45 and thus distorted loop 3 or because the loop 3 is intrinsically disorder in a monomeric enzyme and cannot fit the neighbor molecule that presents higher B-factors in α-helices 4 and 5.