Sonochemotherapy

(A) Timeframe of each sonochemotherapy treatment schedule, arrows indicate intravenous injection of 0.5 ml SonoVue followed by a 5-ml injection of saline, δt represents the time between each injection; (B) Photo of the probe and custom-made probe holder during patient treatment; (C) Changes in tumor diameter over time measured from CT images in patients with pancreatic malignancy.