Sympathoinhibitory

The current studies strongly suggest the PVN as the locus of the observed actions of central Gαi 2 proteins, however future microinjection studies, designed to down-regulate Gαi 2 proteins site-specifically within the PVN are required to definitively establish the PVN as a brain site in which Gαi 2 protein pathways act to produce sympathoinhibitory influences on the renal handling of sodium and water to counter the development of salt-sensitive hypertension.