Unanaesthetized

On August 31, 1950, another V-2 was launched and carried an unanaesthetized mouse that was photographed in flight and did not survive impact.

They argued with him that it would be quite impossible for him to stand unanaesthetized the elaborate cutting and dissection necessary to complete an operation of this kind in a most important part of the body, where large nerves and arteries would have to be cut through and where the slightest disturbance on the part of the patient might easily lead to serious or even fatal results.