Uptitrated

A total of 244 patients, uptitrated to the high drug dose of zofenopril ( n = 130) or irbesartan ( n = 114), entered the double-blind extension phase and were followed for 30 weeks; 223 of them were included in the intention-to-treat analysis for this period (119 in the zofenopril plus hydrochlorothiazide and 104 in the irbesartan plus hydrochlorothiazide treatment group).