Uptitration

Somewhat counterintuitively, but perhaps due to indirect effects on the renin–angiotensin system, Scherer and colleagues (2013) found that appropriate uptitration of BBs improves HRQoL in elderly HF patients with reported benefits in general health, vitality, and physical function, although physical capacity was not objectively quantified. Regarding the renin–angiotensin–aldosterone system, as discussed above, administration of ACE inhibitors in normal aging may have a modest effect in slowing the progression of muscle-related weakness, although results are variable.