This adjustable biomodulation of substrates can, on one hand, lead to the transmission of signals participating in the cell cycle and cell proliferation control, but on the other hand, their role in the regulation of apoptosis (indirectly or through a direct effect on its substrates, including caspases or Bcl-2 protein family members, such as Bcl-2, Bcl-xL, Bid, Bax) is postulated [11 ,16 ,21 –23 ].
Source: wiktionary