Some isotopes that are not alpha-emitters are also "bone[-]seekers," and are not well eliminated. The result is that even a small quantity of these materials, retained in the body, may lead to depression of bone marrow activity, and to serious bone lesions.
Source: wiktionary
The bases of working limits for environmental contamination are the permissible limits for internal emitters. If the internal emitter is a bone-seeker (examples are plutonium, Sr⁹⁰, and the rare earths) the criterion for establishing limits is based on the history of humans who have had radium deposited in their skeletons. To experimentally find the maximum quantity of a radioactive bone-seeker that can deposit in the human skeleton without adverse effect, it is usual to compare the toxicity in experimental animals of the bone-seeker with that of radium.
Source: wiktionary
In general, localization of the rare-earth "bone-seekers" was poor except for ¹⁵⁷Dy, which compared well with ⁹⁹ᵐTc-PP and ⁹⁹ᵐTc-DP; ¹⁵⁷Dy was also helpful in studies of the abdomen and pelvis because of its failure to concentrate in the gastrointestinal tract.
Source: wiktionary
These studies demonstrated that beside radionuclide retention anatomical and physiological factors affect the induction of radiation damage from incorporating α-emitting bone seekers to bone marrow.
Source: wiktionary
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