This observation may indicate a different population of cells, most probably NSC. In order to answer this question, we assessed the coimmunoreactivity of nestin (a NSC marker) with ApoE in the SGZ. LXR agonist treatment of 3xTg-AD mice increased the area of nestin staining as compared with untreated 3xTg-AD animals by 2 folds (P = 0.01).
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