Repeated AOD exposure also can lead to adaptations in the reward circuitry that oppose and neutralize a drug's effects (i.e., counteradaptation).
Source: wiktionary
Counteradaptation
Synonyms for "counteradaptation"
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Counteradaptation postulates that the initial positive rewarding feelings are followed by the opposing development of tolerance.
Source: wiktionary
The conceptual framework of opponent process counteradaptation involves an initial a-process (positive hedonic effect; "light side") occurring shortly after presentation of the reinforcer followed by a b-process (negative hedonic effect; "dark side") appearing after the a-process has terminated.
Source: wiktionary
Sensitization and counteradaptation are two of the major neuroadaptive models that have been proposed to explain how changes that start in the reward pathway may result in the development of substance dependence.
Source: wiktionary
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