[T]here is no doubt but the facture or framing of the inward parts, is as full of difference, as the outward, and in that, is the Cauſe Continent of many diſeaſes, which not be obſerued, they quarrell many times with the humors which are not in fault, the fault being in the very frame and Mechanicke of the parte, which cannot be remoued by medicine alteratiue, but muſt be accomodate and palliate by dyets and medicines familiar.
Source: wiktionary