Insanify

There may be, at present, some very respectable men at the head of these maniacs, who would insanify them with some degree of prudence, and keep them only half mad, if they could. But this won't do; Bedlam will break loose, and overpower its keepers.

Source: wiktionary

Under the insanifying influence produced by the horrors of the French Revolution, and the angry excitement of the war then raging, every Review was perverted into an instrument of political animosity and religious, or rather of ir-religious, hatred.

Source: wiktionary