Retrospectively, some findings like rigid spine in patient II-2, early ventilatory failure despite preserved ambulance in subjects II-2 and III-1, core-like lesions in patients II-2 and II-7, and fibers showing minicores or expressing αβ-Crystallin in subject II-7 are consistent with a myopathy caused by SEPN1 defects [26, 28 –30 ].
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