Because no precursorial shock wave is present, because of a center focal point for the shockwave, and because of the lower pressure of shock wave in this machine, the patient feels no pain and it is possible to treat without any kind of anesthesia, including IV sedation.
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Later the thick filaments acquired a more compact, regular arrangement to form interrupted series of structural units (sarcomeres), on which precursorial M-lines and H-bands could then be noted.
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The presence of these precursorial forms of the hormones was initially demonstrated by gel filtration chromatography and radioimmunoassay of glandular tissue extracts.
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He claimed that the seeming 'precursorial' colonies of fossils were the result of younger rocks having been faulted into older strata ( Notebook IV, 3 July 1879), as shown in Figure 5.1.
Source: wiktionary