Nearly 10% of patients infected by Schistosoma mansoni progress to the most severe form, hepatosplenic (HS) schistosomiasis, which is characterized by periportal fibrosis (PPF), obstruction by eggs of intrahepatic veins, presinusoidal portal hypertension, splenomegaly, hemodynamic and lipid abnormalities, frequently resulting in upper digestive bleeding [3 –5 ].
Source: wiktionary