Sympatheticolytic

Other pharmacologic actions include the cyanosis of the coxcomb, rather slight sympatheticolytic (epinephrine-reversal) action, slight rise in blood pressure, depression of frog’s heart, mydriasis in rabbits (M. E. Davis, Adair, Chen and Swanson, 1935).

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Our own observations—particularly in those experiments in which marked variations of the electrocardiogram during the hot-air bath were reduced or disappeared after application of a sympatheticolytic drug—often showed typical sympatheticotonic variations during the pyrexia and vagotonic variations after its completion (Fig. 2).

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At this time, the rationale for the use of ergotamine was that, contrary to the interpretation that had prevailed in earlier years, migraine headache depended on excessive rather than decreased sympathetic activity, and that ergotamine had a sympatheticolytic rather than a sympathomimetic effect.

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Cocaine diminished considerably the hypertensive effect, which is not reversed by the sympatheticolytic F. 883.

Source: wiktionary