Monoester

Frederick B. Power and Frank Tutin have experimentally confirmed the observations of Carré, that at temperatures above 110° the interaction between phosphoric acid and glycerole results in the production of varying amounts of diester accompanying the monoester or glycerophosphoric acid.

For example, hydrolysis of diesters (Fig. 1) separated by a long methylene chain exhibits equal rate constants at each site (k₁ = k₂), which sets an upper limit of 36.8% for the yield of the monoester.

Twenty healthy individuals participated in the study and on two occasions consumed the ketone monoester supplement or a placebo after a 10-hour fast.