Frederick B. Power and Frank Tutin have experimentally confirmed the observations of Carré, that at temperatures above 110° the interaction between phosphoric acid and glycerole results in the production of varying amounts of diester accompanying the monoester or glycerophosphoric acid.
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For example, hydrolysis of diesters (Fig. 1) separated by a long methylene chain exhibits equal rate constants at each site (k₁ = k₂), which sets an upper limit of 36.8% for the yield of the monoester.
Source: wiktionary
Twenty healthy individuals participated in the study and on two occasions consumed the ketone monoester supplement or a placebo after a 10-hour fast.
Source: wiktionary