We report here the successful use of a new repository sulphone, acedapsone, in a field trial in Micronesia, both for the treatment of active leprosy cases and for the prevention of leprosy in an exposed, highly susceptible population.
Source: wiktionary
In the 1960s and 1970s chemoprophylaxis with dapsone and acedapsone was investigated.
Source: wiktionary
The more intense effect arises, of course, from the relatively facile non-enzymatic hydrolysis of these compounds as opposed to the enzyme-dependent hydrolysis of acedapsone.
Source: wiktionary