The transcription factor T-bet promotes naive CD8 + T-cell differentiation to effector cytotoxic T lymphocytes (CTL) [13 –14 ], expressing CD25 (IL-2R-α), IL-12 receptor (IL-12R) and IFN-γR. TLR2, forming heterotypic associations with TLR1 or TLR6, recognizes triacetylated or diacetylated lipopeptides, respectively [15 –17 ].
Source: wiktionary