Autoimmunity
noun ·Rare ·Advanced level
Definitions
- 1 The condition where one's immune system attacks one's own tissues, i.e., an autoimmune disorder. countable, uncountable
"This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have on the development of disease."
- 2 production of antibodies against the tissues of your own body; produces autoimmune disease or hypersensitivity reactions wordnet
Example
More examples"This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have on the development of disease."
Etymology
From auto- + immunity.
Related phrases
More for "autoimmunity"
Data sourced from Wiktionary, WordNet, CMU, and other open linguistic databases. Updated March 2026.