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Embitter

//ɪmˈbɪtə// verb

Verb

1
To cause (something) to be or taste bitter; to bitter. archaic, transitive
2
cause to be bitter or resentful wordnet
3
To cause (a positive quality such as happiness, or a thing such as an activity or one's life) to become less good or pleasurable; also, to make (a negative quality, or thing such as a disagreement) worse or more unpleasant. figuratively, transitive
"He imbitters not a diſtaſtfull meſſage to a forrein Prince by his indiſcretion in delivering it."
4
To cause (someone or their feelings) to become more angry, resentful, or unfriendly; to envenom. figuratively, transitive
"Sometimes it [pride] ſtirreth vp men, and imboldeneth them to offer vvrongs: ſometimes imbittereth men; and maketh them vvayvvard againſt the right: […]"

From em- (variant of the suffix en- with the sense ‘to become’) + bitter.

Unscramble this word: embitter