What does "extramedullary" mean?
Outside of a medulla.; Outside of the bone marrow, as with extramedullary hematopoiesis.
Extramedullary
/ˌɛkstɹəməˈdʌləɹi/ adj
adj ·Rare ·Advanced level
Meaning at a glance
- Primary sense: Outside of a medulla.; Outside of the bone marrow, as with extramedullary hematopoiesis.
- Grammar: extramedullary is listed as adj.
- Useful contrasts: medullary, myelic.
- Usage evidence: Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. The most common sites of EMH are liver and spleen, but it has been documented in other organs such as the mediastinum, lymph nodes, breast, and central nervous system. EMH occurs as a compensatory mechanism for bone marrow dysfunction in severe thalassemia.
How to use "extramedullary"
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Source and review context
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Definitions
Adjective
- 1 Outside of a medulla.; Outside of the bone marrow, as with extramedullary hematopoiesis. not-comparable
"Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. The most common sites of EMH are liver and spleen, but it has been documented in other organs such as the mediastinum, lymph nodes, breast, and central nervous system. EMH occurs as a compensatory mechanism for bone marrow dysfunction in severe thalassemia."
- 2 Outside of a medulla.; Outside of the medulla oblongata, as with extramedullary influences on control of ventilation. not-comparable
"As no complete study has been made of reflex response to stimulation of ipsilateral vagus in regard to extramedullary respiratory control system, the authors have tried to clarify the influence of the stimulation of the vagus on the ipsilateral posterior cricoarytenoid muscle (PCA)."
- 3 Outside of a medulla.; Outside of the renal medulla, as with extramedullary electrolytes or renal tissue. not-comparable
"Similar mechanisms likely underlie the expression of relevant transporters and/or enzymes for the alternative nonperturbing osmolytes (11,12,35) in renal medullary tubular cells. Osmotic induction of AR2 and MI transport has also been described in extramedullary renal cells and in nonrenal cells rarely or never exposed to significant physiologic hyperosmolarity in vivo (31,39)."
- 4 Outside of a medulla.; Outside of the spinal cord, as with intrameningeal but extramedullary tissues of the central nervous system. not-comparable
"This paper reports on neoplastic disease of the spine and spinal cord. Spinal tumors are often categorized as extradural, intradural–extramedullary, or intramedullary in location. This classification represents somewhat of an over-generalization for two reasons. First, a given lesion may reside in two compartments simultaneously. […] Second, in different cases, two lesions with identical pathology may occur in different compartments. […] Nevertheless, this classification scheme is useful, because it is traditional and helps to characterize spinal tumors."
Example
"Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. The most common sites of EMH are liver and spleen, but it has been documented in other organs such as the mediastinum, lymph nodes, breast, and central nervous system. EMH occurs as a compensatory mechanism for bone marrow dysfunction in severe thalassemia."
Common questions
How do you use "extramedullary" in a sentence?
Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. The most common sites of EMH are liver and spleen, but it has been documented in other organs such as the mediastinum, lymph nodes, breast, and central nervous system. EMH occurs as a compensatory mechanism for bone marrow dysfunction in severe thalassemia.
How do you pronounce "extramedullary"?
Pronounced /ˌɛkstɹəməˈdʌləɹi/.
Etymology
From extra- + medullary or extra- + medulla + -ary.