Consternation

He looked at me with consternation, saying that he must put a comma somewhere.

I learned with consternation that my fears had come to pass.

Tom looked in consternation at the stain on his shirt.

The consternation was general.

Esau having heard his father's words, roared out with a great cry; and, being in a consternation, said: Bless me also, my father.

The appearance of these variants has triggered consternation and many questions regarding their potential impact on the efficacy of newly developed vaccines against the coronavirus.

"Out!" exclaimed her husband, with something like genuine consternation in his voice.

Their audience had been listening in increasing consternation.

It was probably worth four millennia of consternation and regret.