Deranging

It offends against Christian ethics by not tracing the grounds of human obligation to their ultimate source in God; but while Buddhism equally fails in this respect, its teachings, if practically carried out, in magnifying the duty of retiring from the world to escape its evils, and to make progress in virtue, would prove more deranging and disintegrating to society than those of Confucianism, and so less in harmony with the true standard of social ethics.

The nightmare on the shucks experienced by young Bayard becomes, in Sanctuary, exponentially more deranging.

Over-communication can be more deranging than cannabis ...

I had never taken a drug more deranging than aspirin and the milder antibiotics.