Glucoregulatory

Some of the known glucoregulatory effects of narcotic drugs and endogenous opioid peptides may participate in the proposed role of the opioid system in the adaptation to starvation.

Overall, these data suggest that the glucoregulatory benefits for TGR5 agonists in rodents for the treatment of diabetes and metabolic syndrome likely cannot be separated from concurrent pharmacology in the gallbladder.