Goitrogenic

The present studies demonstrate that iodine depletion increases the sensitivity of the thyroid to the goitrogenic effects of thyrotropin.

Seventy-eight compounds were screened for goitrogenic action. Of these, 12 were found to be effective, but only thiouracil, propylthiouracil, 2-amino-thiazole and Dithane were found to be markedly active.