Haemoglobinopathy

Simpler tools for detecting sickle haemoglobin made analysis of the malaria hypothesis in the context of this haemoglobinopathy that much easier, which has facilitated measurement of the trait against a spectrum of endpoints of protection, such as the infection itself, parasite density in infection, uncomplicated disease, and severe disease, and death.

Active group membership was operationalized as having attended at least one group meeting during the past year, requesting voluntary inclusion on the group’s roster, and having been formally diagnosed with SCD or a related hemoglobinopathy.

The clinical phenotypes of over 125 different hemoglobinopathies were interpreted in terms of structural alterations in globin structure.