Kilter

Ignoring feelings of tiredness knocks our body clocks out of kilter.

not in kilter

[T]hey are either round-shouldered, knock-kneed, bow-legged, or parrot-toed; some are also badly cross-eyed. It seems as if they can see two different ways at the same time. Jack says they are lop-sided and out of kilter altogether.

[H]e lived on tinned tomatoes, beef embalmed and sourdough bread, / On rusty beans and bacon furred with mould; / His stomach’s out of kilter and his system full of lead, / But it's over, and his poke is full of gold.