Thwarting

He's always thwarting my plans for world domination.

He's always thwarting my nefarious plans.

The villain vowed to make Sir Thomas pay for thwarting his ambitions.

[…] the complicated probabilities of an arduous purpose, with all the possible thwartings and furtherings of circumstance, all the niceties of inward balance, by which a man swims and makes his point or else is carried headlong.