In other studies, Othman et al. and Vaccaro et al. synthesized and characterized amphiphilic complex obtained by coupling the hydrophilic DOTA ligand [1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane] to squalenoyl moieties and complexes containing amphiphilic supramolecular aggregates DTPAGlu chelating agent covalently bound to two C18 alkylic chains with a good relaxivity of 15–22 s -1 mM −1 (at 20 MHz and 37°C) and 21.5–24 s -1 mM −1 (at 20 MHz and 25°C), respectively [ 32, 33 ].
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