Strictly speaking, it was not a manuscript at all when first discovered, and bore no title. The superscription “The Handmaid’s Tale” was appended to it by Professor Wade, partly in homage to the great Geoffrey Chaucer; but those of you who know Professor Wade informally, as I do, will understand when I say that I am sure all puns were intentional, particularly that having to do with the archaic vulgar signification of the word tail; that being, to some extent, the bone, as it were, of contention, in that phase of Gileadean society of which our saga treats.
Source: wiktionary