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Keep "hesperides" when the sentence already sounds natural, when a synonym would add unintended emphasis, or when readers need the most familiar wording. A synonym should clarify or sharpen the message, not simply make the sentence look more varied.
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2 total sentences available.
With these words he laid the apple in Chloe's lap, and she, when he drew near to her, gave him a kiss; so that Daphnis did not repent of having climbed so high; for the kiss that he received was to his mind worth even more than the golden apples of the Hesperides.
Source: tatoeba (6213329)
Inclinations no leſs vigorous have of late been obſerved in Europe, but with more ſucceſs; who not being bounded by Herculean Bars, paſt ſo far through (till then) the unmeaſured Atlantick, that they lighted upon a new World, a flouriſhing Heſperides, Regions whoſe Sands were Gold, Earth Plate, and Rivers Silver, a Paradice extended to the Arctick and Antarctick Circles, with ſeveral other Countries and Iſlands that reach almoſt the utmoſt latitude of either Poles, out-ſhining all the Fables of Antiquity, and boldeſt Tales of their Poetick Dreams; […]
Source: wiktionary
Closest matches include atlantides, garden nymph, garden nymphs, nymph, the hesperids.
Compare the replacement against real sentence context. This entry includes sample sentences so you can check tone, grammar, and meaning before swapping words.